Is long-term Melatonin use linked to heart failure?
Melatonin prescriptions lasting over a year were linked to an 89% higher heart failure risk over five years, but this does not prove cause.
The analysis covered health records from more than 130,000 adults across several countries. They had insomnia, meaning ongoing trouble sleeping. Researchers compared people prescribed Melatonin long-term with those without a prescription. The records included the US and UK. In the UK, this supplement is available only by prescription. In the US, people can buy it without one.
The findings also raised concerns beyond heart failure, when the heart cannot pump well enough. A second analysis found almost 3.5 times the risk of hospital stays for heart failure. Deaths from any cause were 7.8% in the long-term prescription group. That compared with 4.3% in the group without prescriptions.
These are early findings, not proof that the supplement caused harm. They were presented at an American Heart Association meeting in November 2025. Other experts had not yet formally reviewed the work. The article also notes that thorough research on long-term safety remains lacking. These records do not settle whether occasional use carries the same concerns.
For BioSocial members, this makes the details of a sleep habit worth recording. Dose, nights used each week, and total months used add useful context. Tracking Sleep Duration alongside those details can help members compare their own numbers. Those notes cannot prove long-term heart safety. But they can make community conversations more useful than simply saying a supplement works.
What have you noticed in your sleep numbers over time, and how often have you used Melatonin?
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