Can stopping Denosumab raise your risk of broken bones?
Yes—stopping treatment was linked to more spine fractures, with the highest odds reported 3–9 months after stopping.
The Microscopic Colitis Foundation blog discusses stopping Denosumab, an injection that slows bone breakdown. It draws on studies of people who stopped treatment for weak bones. One study from 2021 looked back at records from 797 people. A 2025 study compared multiple spine fractures after people stopped different bone medicines.
The blog reports a 5- to 11-fold rise in fracture risk after stopping following 1–5 years of use. Longer prior treatment was linked to greater risk after stopping. The highest odds of multiple spine fractures appeared between 3 and 9 months after stopping. These are reported comparisons, not the number of people out of 100 who broke a bone. The excerpt does not provide those counts or fully explain the comparison groups.
The key takeaway is that stopping is not simply pausing the benefits. The blog warns that treatment gains can be lost. It describes starting this medicine as a long-term commitment in most cases. It also stresses a planned switch to another medicine that slows bone breakdown, rather than stopping without a transition.
For BioSocial members, this makes the treatment timeline worth tracking alongside test results. Injection dates, years of use, and any medication switch add context. Members tracking Bone Mineral Density can compare their own results over time, alongside those dates. Sharing that context makes community notes more useful than comparing one scan result alone.
What have you noticed in your bone scan numbers or treatment timeline while using or transitioning off this medicine?
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