Yes—in a study of 728 adults without diabetes, higher insulin resistance was linked to larger brain grooves, but only in men. Researchers compared HOMA-IR (Insulin Resistance) with brain scans. This score estimates how poorly the body responds to insulin. The study included 518 men and 210 women, with an average age of 61.4 years. Researchers measured fluid-filled spaces in 30 brain regions. They accounted for age, sex, and head size when comparing results. Higher scores were linked to larger grooves at the front of the brain. These are spaces between the brain’s folds. The grooves grew larger across groups with higher insulin resistance. The link was strongest in people younger than 70. It appeared in men, but not women, when researchers looked at each group separately. A standard measure of brain tissue size did not show the same pattern. This suggests that measuring these grooves may pick up differences other measures miss. But a link does not prove cause. The study also does not show that lowering insulin resistance reverses these differences. For BioSocial members, this adds a brain-health angle to tracking this score. It is not a way to read brain health from one blood result. Keeping past results together can make your own trend easier to follow. Comparing notes with the community can also put changes in context. The useful distinction is between tracking a bloodwork trend and assuming what it means for your brain. What patterns have you noticed in your scores over time, and what was changing in your routine?