Ivabradine, a medicine that slows the heart, lowered standing pulse by 18.5 beats per minute on average in people with POTS. POTS is a condition where the heart races too much when standing. A 2026 review combined nine studies involving 245 people with this condition. The studies included children and people who developed POTS after COVID-19. Researchers looked at Standing Heart Rate, pulse while lying down, symptoms, and side effects. The average drop while lying down was smaller: 9.7 beats per minute. People also reported improvements in Palpitations, or a pounding or fluttering heartbeat. Dizziness / Lightheadedness and Exercise Intolerance, meaning trouble handling exercise, also improved across the groups studied. Side effects were uncommon and mild. Temporary changes in vision were the most common. No severe slowing of the heart or low blood pressure was reported. That is encouraging, but these small studies cannot rule out rare problems. The evidence is promising, not settled. Results varied widely, especially in children and people with POTS after COVID-19. Most studies watched people taking the medicine rather than testing it against another treatment. Larger, more rigorous studies are still needed. For BioSocial members, the useful takeaway is to pair numbers with daily experience. A lower reading and an easier day are different things worth tracking together. This review concerns POTS, not everyone with a higher standing pulse. When comparing notes, details about symptoms and measurement routines can give numbers more context. What changes in your Standing Heart Rate have lined up with changes in how you feel while standing?