Creatine made blood-clotting cells more active in healthy volunteers and helped cancer spread in mice. The study examined Platelets, the tiny blood cells that help form clots. Published in Nature Communications in 2026, it included several mouse experiments and healthy volunteers. Researchers explored how added creatine changed these cells and their role in cancer spread. Creatine built up inside the cells that make Platelets. It changed signals inside those cells, making the Platelets they produced overactive. In mice, this helped cancer spread to other parts of the body. Blocking creatine entry or a key signal stopped the extra activity. It also prevented the added cancer spread in mice. Healthy volunteers also developed overactive Platelets after taking creatine. But the supplied summary does not report cancer developing or spreading in those people. The human finding was increased cell activity, not measured cancer outcomes. The summary gives no dose, study length, group size, or size of the effect. That limits what we can conclude about everyday use. For members tracking Platelets, the key distinction is count versus activity. A routine blood count measures how many there are, not how active they are. This finding does not establish that a higher count reveals this effect. If you log Creatine Monohydrate, keeping dates and amounts alongside bloodwork can support clearer community comparisons. Those notes provide context, but cannot confirm the effect seen here. What have you noticed in your Platelets results while tracking your supplement habits?