Yes—in this study, average levels of a gut-related blood marker fell by half after 12 weeks of constipation treatment. The marker was TMAO (Trimethylamine N-Oxide), a substance linked to gut bacteria and heart health risk. Researchers at three Japanese centers followed 165 people with long-term constipation. They also measured levels in 72 healthy people for comparison. Before treatment, average blood levels were 9.0 in people with constipation versus 1.8 in healthy people. These values were measured in micromoles per liter, a measure of blood concentration. Levels were higher when waste moved slowly through the bowel. That group included 55 people. The other 110 had constipation despite waste moving at a normal speed. People received magnesium oxide or elobixibat, two medicines used to treat constipation. Average levels fell to 5.5 after four weeks and 4.5 after 12 weeks. The response differed by medicine and bowel speed. Elobixibat lowered levels at both checks in both groups. Magnesium oxide lowered levels only at 12 weeks in the normal-speed group. It did not lower levels in the slow-moving group. The study tracked treatment rather than assigning it by chance. That limits what it can prove about cause and effect. It also did not show that lower blood levels led to fewer heart problems. For BioSocial members, bowel habits may offer useful context for bloodwork trends. Recording symptoms, treatment changes, and test dates could make community comparisons more meaningful. The group average is a reference point, not a promised result. What changes have you noticed in your blood results alongside changes in constipation or bowel habits?