Yes—liver blood test levels rose in 75% to 82% of people after keyhole gallbladder surgery, then returned to earlier levels by day 7. A 2026 review in *Updates in Surgery* covered 52 studies. Together, they included more than 28,000 people having surgery for gallstones. The review focused on keyhole surgery, which removes the gallbladder through small cuts. Two liver tests showed the most common rise: AST (Aspartate Aminotransferase) and ALT (Alanine Aminotransferase). These tests measure proteins called enzymes in the blood. Levels rose 24 to 48 hours after surgery. The return to earlier levels by day 7 was a key finding. Other tests showed smaller changes. Mild rises occurred in 10% to 30% of people for Alkaline Phosphatase (ALP), GGT (Gamma-Glutamyl Transferase), and Bilirubin (Total). Longer operations and higher pressure inside the belly during surgery were linked to enzyme changes. The review reported no harmful health outcomes from these short-lived changes. Its authors suggested routine liver testing may be unnecessary for low-risk people. They also called for closer, individual assessment of people at higher risk. That does not mean every high result after surgery follows this pattern. For BioSocial members, the timing of a blood draw matters. A result two days after surgery may tell a different story than one a week later. Adding the surgery date to uploaded bloodwork can help put changes in context. Comparing results before and after surgery also makes community discussions more useful than sharing one isolated number. If you had gallbladder surgery, how did your liver blood test results change over the following week?